Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics
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چکیده
منابع مشابه
Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics.
BACKGROUND Signalling of several G-protein-coupled receptors of the Gq/11 family is time-dependently inhibited by local anaesthetics (LAs). Since LA-induced modulation of muscarinic m1 and m3 receptor function may explain their beneficial effects in clinical practice, such as decreased postoperative cognitive dysfunction or less bronchoconstriction, we studied how prolonged exposure affects mus...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2014
ISSN: 0007-0912
DOI: 10.1093/bja/aet299